Physiotherapy clinic in Tambaram Are you Lookin...

Physiotherapy clinic in Tambaram Are you Looking for Physiotherapy Treatment in Tambaram, Sunshine Super Speciality Physiotherapy Clinic, We Provide Electrotherapy, Exercise and Manual Therapy, Orthopedic, Neuro, Cardio, Pediatric, Sports and Geriatric Rehabilitation, Post Operative Physiotherapy Treatment, Fracture Rehabilitation, pain free movement. Intervertebral disc injury may trigger neurogenic inflammation of adjacent healthy discs 💡 👉Animal and human studies have shown that the nerve fibers of the normal lumbar disc are only distributed in the outer layer of the annulus fibrosus, but in the degenerative disc, the nerve fibers grow deeply into the inner layer of the annulus fibrosus and even the nucleus pulposus ). 👉 The sensory nerve fibers that supply the lumbar disc consist mainly of small myelinated A-delta fibers and unmyelinated C-fibers. These tiny fibers express neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP), which are nociceptorsassociated with inflammatory pain. They are NGF-dependent and express high-affinity tyrosine kinase A (TrkA) receptors, suggesting that they are the main source of disc-derived nociceptive stimuli (). 👉In case of dis injuries, a combination of pro-nociceptive mediators such as serotonin, bradykinin, NGF, PGE2, and proton is produced at the site of intervertebral disc injury. These mediators interact with their receptors or ion channels on sensory nerve endings to activate nociceptors in the inflammatory region (). Because nociceptors can release neuropeptides SP and CGRP from their peripheral terminals when activated by noxious stimuli, these neuropeptides can act as proinflammatory molecules, promoting the production of inflammatory soup by inducing vasodilation and plasma extravasation, as well as by promoting the release of chemical mediators by disc cells or infiltrating immune cells and vascular tissue 👉 Neuron that releases neuropeptides SP and CGRP at one terminal will release them at all its terminals (). In other words, this biologically important release from a peripheral afferent terminal can be initiated by antidromic activity from the proximal anatomic afferent collaterals of the target organ. Thus, antidromic information may be transmitted throughout the peripheral receptive area of the axon ). The nerves that pass through the inflammatory environment can discharge bi-directionally, not only causing referred pain in the innervated structure, but also producing corresponding neurogenic inflammation antidromically on the same structure. 👉 As one lumbar disc is innervated by multiple dorsal root ganglia, and an axon innervating a disc may send out multiple collaterals simultaneously to innervate multiple adjacent discs SUNSHINE ® SUPER SPECIALITY PHYSIOTHERAPY CLINIC - #DrParthiban #Sunshinephysioclinic.in #Physiotherapyclinicintambaram #Physiotherapyclinicnearme DR.M.P. PARTHIBAN.M.P.T (Ortho), Chief Orthopedic Physiotherapist, Call for Appointments: - 9345122177 East Tambaram, CHENNAI